circRNA basic information
circBase ID: hsa_circ_0043216
Name: hsa_circ_ACACA
Synonym: circACACA
Host Gene: hsa-miR-193a-3p, hsa-miR-193b-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal tumorigenesis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (HT29, SW480, HCT116, RKO, SW620), normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HDAC3
Associated microRNA: hsa-miR-193a-3p, hsa-miR-193b-3p
Biological function: circACACA downregulation effectively delayed CRC cell proliferation and metastasis
Molecular mechanism: circACACA/hsa-miR-193a-3p/hsa-miR-193b-3p/HDAC3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

circACACA promoted CRC progression via regulating the miR-193a/b-3p/HDAC3/p53 axis to activate the MVA pathway, providing evidence for circACACA as a promising therapeutic target for CRC.
Other information
Title:

Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.

Journal: Mol Carcinog
Published: 2023/3/16
PubMed ID: 36920044