circRNA basic information
circBase ID: hsa_circ_0007905
Name: hsa_circ_STX6
Synonym: circ_0007905
Host Gene: hsa-miR-6749-3p
 
 
 
Disease basic information
DO ID:
 0070353
DO name: cataract
Disease details: cataract
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lens epithelial cell line (HLE-B3)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: EIF4EBP1
Associated microRNA: hsa-miR-6749-3p
Biological function: Silencing of has_circ_0007905 promoted proliferation and inhibited the apoptosis of HLE-B3 cells
Molecular mechanism: METTL3/has_circ_0007905/hsa-miR-6749-3p/EIF4EBP1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

We reveal for the first time that the commitment of ARC progression is guided by METTL3/has_circ_0007905/miR-6749-3p/EIF4EBP1 axis, and the results provide new insights into ARC pathology.
Other information
Title:

METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1.

Journal: PeerJ
Published: 2023/3/14
PubMed ID: 36908822