circRNA basic information
circBase ID: hsa_circ_0000741
Name: hsa_circ_POLR2A
Synonym: circ_0000741
Host Gene: hsa-miR-379-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioblastoma cells (A172, U251), normal human astrocytes (NHAs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRIM14
Associated microRNA: hsa-miR-379-5p
Biological function: circ_0000741 absence reduced SAHA tolerance, suppressed proliferation, invasion, and induced apoptosis in SAHA-tolerant GBM cells
Molecular mechanism: circ_0000741/hsa-miR-379-5p/TRIM14 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0000741 might accelerate SAHA tolerance by regulating the miR-379-5p/TRIM14 axis, which provided a promising therapeutic target for GBM treatment.
Other information
Title:

Circular RNA circ_0000741/miR-379-5p/TRIM14 signaling axis promotes HDAC inhibitor (SAHA) tolerance in glioblastoma.

Journal: Metab Brain Dis
Published: 2023/3/12
PubMed ID: 36905560