circRNA basic information
circBase ID: hsa_circ_0003645
Name: hsa_circ_C16orf62
Synonym: circ-C16orf62
Host Gene: hsa-miR-377
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: Atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human monocytic THP-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAB22A
Associated microRNA: hsa-miR-377
Biological function: Apoptosis, inflammation, oxidative stress and cholesterol accumulation induced by ox-LDL were suppressed by circ-C16orf62 knockdown
Molecular mechanism: circ-C16orf62/hsa-miR-377/RAB22A axis
Survival: -
Supported No.:
 3
Description:

In conclusion, circ-C16orf62 played a crucial role in the regulation of apoptosis, inflammation, oxidative stress and cholesterol accumulation in ox-LDL-treated human macrophages via mediating the miR-377/RAB22A axis, hinting that circ-C16orf62 might be involved in AS progression.
Other information
Title:

Circ-C16orf62 Regulates Oxidized low-density Lipoprotein-induced Apoptosis, Inflammation, Oxidative Stress and Cholesterol Accumulation of Macrophages via Mediating RAB22A Expression by Targeting miR-377.

Journal: Appl Biochem Biotechnol
Published: 2023/3/10
PubMed ID: 36892682