circRNA basic information
circBase ID: hsa_circ_0006421
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: hsa-miR-766
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Alveolar type II cells (RLE-6TN; ATCC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: eIF5A
Associated microRNA: hsa-miR-766
Biological function: knockdown of circPTK2 effectively ameliorated LPS-induced ATP efflux, pyroptosis, and inflammation
Molecular mechanism: circPTK2/hsa-miR-766/eIF5A axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, circPTK2/miR-766/eIF5A axis ameliorates septic ALI, developing a novel therapeutic target for the disease.
Other information
Title:

Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.

Journal: Acta Cir Bras
Published: 2023/3/9
PubMed ID: 36888755