circRNA basic information
circBase ID: hsa_circ_0001361
Name: hsa_circ_FNDC3B
Synonym: circ-FNDC3B
Host Gene: hsa-miR-136-5p, hsa-miR-370-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: ESCC cell lines (ECA109, OE33, TE1, KYSE410)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MYO5A, MYO5A
Associated microRNA: hsa-miR-136-5p, hsa-miR-370-3p
Biological function: Downregulation of circ-FNDC3B inhibited ESCC cell proliferation and invasion but accelerated cell apoptosis.
Molecular mechanism: circ-FNDC3B/hsa-miR-136-5p/MYO5A axis, circ-FNDC3B/hsa-miR-370-3p/MYO5A axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

These findings demonstrated that circ-FNDC3B contributed to malignant progression of ESCC cells via miR-136-5p/MYO5A or miR-370-3p/MYO5A axis.
Other information
Title:

Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p.

Journal: Biochem Genet
Published: 2023/3/9
PubMed ID: 36884165