circRNA basic information
circBase ID: hsa_circ_0000098
Name: hsa_circ_SLC30A7
Synonym: circ-0000098
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: four HCC cell lines (Hep3B, Huh7, MHCC97L, SKhep1), normal human liver cell line (THLE-21)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: MMP2
Associated microRNA: hsa-miR-136-5p
Biological function: We also proved that the migration and invasion abilities of HCC cell lines can be inhibited by silencing hsa_circ_0000098
Molecular mechanism: hsa_circ_0000098/hsa-miR-136-5p/MMP2 axis, miRNA sponge
Survival: poor
Supported No.:
 4
Description:

we demonstrated that the mechanism of action of hsa_circ_0000098 in HCC might be due to the regulation of miR-136-5p/MMP2 axis.
Other information
Title:

Hsa-circ-0000098 promotes the progression of hepatocellular carcinoma by regulation of miR-136-5p/MMP2 axis.

Journal: Adv Clin Exp Med
Published: 2023/3/8
PubMed ID: 36881359