circRNA basic information
circBase ID: -
Name: hsa_circ_SP3
Synonym: circSP3
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (Hep-3B, Huh-7, Bel-7402, SMMC-7721), a normal liver cell line (HL-77O2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: cyclin-dependent kinase 4
Associated microRNA: hsa-miR-198
Biological function: Silencing circSP3 inhibited HCC cell proliferation and migration
Molecular mechanism: by sponging microRNA-198 and upregulating cyclin-dependent kinase 4
Survival: -
Supported No.:
 1
Description:

Silencing circSP3 inhibited HCC cell proliferation and migration by downregulating cyclin-dependent kinase 4, whereas inhibiting miR-198 reversed those effects.
Other information
Title:

Circular RNA circSP3 promotes hepatocellular carcinoma growth by sponging microRNA-198 and upregulating cyclin-dependent kinase 4.

Journal: Aging (Albany NY)
Published: 2021/7/28
PubMed ID: 34314379