circRNA basic information
circBase ID: hsa_circ_0135889
Name: hsa_circ_AGO2
Synonym: circAGO2
Host Gene: hsa-miR-1-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human colon epithelial cells (FHC), CRC cell lines (HT29, HCT116, LOVO, SW620, RKO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RBBP4
Associated microRNA: hsa-miR-1-3p
Biological function: CircAGO2 promoted the growth and invasion of CRC cells
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

CircAGO2 overexpression decoyed miR-1-3p to increase RBBP4 expression, which inhibited HSPB8 transcription via histone deacetylation in HSPB8 promoter region, promoting proliferation and invasion of CRC cells.
Other information
Title:

CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.

Journal: Funct Integr Genomics
Published: 2023/3/8
PubMed ID: 36881338