circRNA basic information
circBase ID: hsa_circ_0012535
Name: hsa_circ_ZCCHC11
Synonym: circ_0012535
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 10533
DO name: viral pneumonia
Disease details: infantile pneumonia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IL6R
Associated microRNA: hsa-miR-338-3p
Biological function: Knockdown of circ_0012535 recovered LPS-inhibited cell viability and proliferation and attenuated LPS-induced cell apoptosis, cell cycle arrest, inflammation, and oxidative stress
Molecular mechanism: circ_0012535/hsa-miR-338-3p/IL6R axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0012535 supported LPS-induced WI38 cell apoptosis and inflammation to promote the progression of infantile pneumonia, and circ_0012535 functioned partly by targeting the miR-338-3p/IL6R signaling.
Other information
Title:

Circ_0012535 Contributes to Lipopolysaccharide-Induced Fetal Lung Fibroblast Apoptosis and Inflammation to Regulate Infantile Pneumonia Development by Modulating the Mir-338-3p/Il6r Signaling.

Journal: Shock
Published: 2023/3/5
PubMed ID: 36870073