circRNA basic information
circBase ID: hsa_circ_0000591
Name: hsa_circ_MGA
Synonym: circMGA
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human immortalized uroepithelium cell line (SV-HUC-1), bladder cancer cell line (UMUC3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HNRNPL, CCL5
Associated microRNA: -
Biological function: we uncover circMGA as a tumor-suppressing circRNA triggering CD8+ T cells chemoattraction and boosting the immunotherapy efficacy
Molecular mechanism: circMGA/HNRNPL/CCL5 axis
Survival: -
Supported No.:
 1
Description:

Taken together, the results demonstrate that circMGA/HNRNPL complex may be targetable for cancer immunotherapy and the study advances our understanding of the physiological roles of circRNAs in antitumor immunity.
Other information
Title:

Regulation of CD8(+) T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer.

Journal: Oncogene
Published: 2023/3/4
PubMed ID: 36869127