circRNA basic information
circBase ID: hsa_circ_0072568
Name: hsa_circ_PDE4D
Synonym: circPDE4D
Host Gene: hsa-miR-569
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colorectal epithelial cell lines (NCM460), CRC cell lines (HCT116, DLD1, Caco-2, HT-29, SW480, HCT-15, LS174T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SPI1
Associated microRNA: hsa-miR-569
Biological function: Transfection with si-circPDE4D promoted cell proliferation, migration, and invasion, and inhibited apoptosis in DLD1 cells. Transfection with LV003-circPDE4D showed the opposite effect. Si-circPDE4D or lv003-circPDE4D. Moreover, si-circPDE4D transfection inhibited cell apoptosis, while LV003-circPDE4D induced apoptosis in HCT116/L cells. transfection increased or decreased cell proliferationin in both two cells.
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

LV003-CircPDE4D reduced hsa-miR-569 expression while increasing SPI1 expression in HCT116/L. CircPDE4D could inhibit tumorigenesis and progression of both CRC and oxaliplatin-resistant CRC, providing insight for the development of therapeutic strategies.
Other information
Title:

Tumor suppressor circPDE4D inhibits the progression of colorectal cancer and regulates oxaliplatin chemoresistance.

Journal: Gene
Published: 2023/3/2
PubMed ID: 36858188