circRNA basic information
circBase ID: hsa_circ_0002316
Name: hsa_circ_OMA1
Synonym: circOMA1
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 5394
DO name: prolactinoma
Disease details: prolactinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: rat prolactinoma cell line (MMQ, ATCC CRL-10609)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Nrf2, GPX4, and xCT
Associated microRNA: hsa-miR-145-5p
Biological function: circOMA1 promoted MMQ cells growth in vivo and in vitro
Molecular mechanism: circOMA1/Nrf2/GPX4/xCT
Survival: -
Supported No.:
 1
Description:

The present study demonstrates that circOMA1 attenuates CAB efficacy through ferroptosis resistance and may be a new therapeutic target for the individualized treatment of DA-resistant prolactinoma patients.
Other information
Title:

CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.

Journal: J Endocrinol Invest
Published: 2023/3/1
PubMed ID: 36853491