circRNA basic information
circBase ID: hsa_circ_0000069
Name: hsa_circ_STIL
Synonym: circSTIL
Host Gene: hsa-miR-431
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: a normal colonic epithelial cell line (NCM460), four human CRC cell lines (HCT116, SW480, LoVo, HT29)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC7A11
Associated microRNA: hsa-miR-431
Biological function: Cell proliferation was suppressed while ferroptosis was induced with the silencing of circSTIL in CRC cells
Molecular mechanism: circSTIL/hsa-miR-431/SLC7A11 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

CircSTIL promotes CRC cell proliferation and suppresses ferroptosis in vitro via miR-431/SLC7A11 signaling, revealing the pathogenesis of CRC, and providing potential therapeutic targets of CRC.
Other information
Title:

CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR-431/SLC7A11 axis.

Journal: Environ Toxicol
Published: 2023/2/26
PubMed ID: 36840697