circRNA basic information
circBase ID: hsa_circ_0017076
Name: hsa_circ_GNG4
Synonym: circRNA_0017076
Host Gene: hsa-miR-185-5p
 
 
 
Disease basic information
DO ID:
 0050855
DO name: renal fibrosis
Disease details: renal interstitial fibrosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human kidney-2 (HK-2) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STIM1
Associated microRNA: hsa-miR-185-5p
Biological function: In vitro, the knockdown of circRNA_0017076 inhibited the calcium ion (Ca2+) influx-mediated epithelial-to-mesenchymal transition (EMT) of RTECs and downregulated the expression of stromal interaction molecule 1 (STIM1)
Molecular mechanism: circRNA_0017076/hsa-miR-185-5p/STIM1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

we identified circRNA_0017076 as a sponge for miR-185-5p, which regulates STIM1 gene expression and is involved in RIF.
Other information
Title:

CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.

Journal: Hum Cell
Published: 2023/2/25
PubMed ID: 36828974