circRNA basic information
circBase ID: hsa_circ_0068631
Name: hsa_circ_TFRC
Synonym: circ_0068631
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 3151
DO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HOXB7
Associated microRNA: hsa-miR-139-5p
Biological function: circ_0068631 silencing could inhibit CSCC cell proliferation and metastasis while promoting apoptosis in vitro, as well as restrain CSCC tumor growth in vivo
Molecular mechanism: circ_0068631/hsa-miR-139-5p/HOXB7 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0068631 functioned as a novel oncogene in CSCC progression by regulating miR-139-5p/HOXB7 axis, suggesting that circ_0068631 may be a potential target for CSCC treatment.
Other information
Title:

Circ_0068631 sponges miR-139-5p to promote the growth and metastasis of cutaneous squamous cell carcinoma by upregulating HOXB7.

Journal: Skin Res Technol
Published: 2023/2/25
PubMed ID: 36823512