circRNA basic information
circBase ID: hsa_circ_0000376
Name: hsa_circ_PRH1-PRR4
Synonym: circ_0000376
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cell line (16HBE), lung adenocarcinoma cell line (H522), NSCLC cell line (A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDPK1
Associated microRNA: hsa-miR-545-3p
Biological function: circ_0000376 knockdown repressed NSCLC cell proliferation, migration, invasion, and glutaminolysis but induced cell apoptosis
Molecular mechanism: circ_0000376/hsa-miR-545-3p/PDPK1 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

Collectively, circ_0000376 regulated NSCLC cell tumor properties by the miR-545-3p/PDPK1 axis, suggesting that circ_0000376 could be employed as a therapeutic target for NSCLC.
Other information
Title:

circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway.

Journal: Open Med (Wars)
Published: 2023/2/24
PubMed ID: 36820067