circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: cSMARCA5
Host Gene: hsa-miR-17-3p, hsa-miR-181b-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: SMMC-7721, HCCLM3
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: TIMP3
Associated microRNA: hsa-miR-17-3p, hsa-miR-181b-5p
Biological function: inhibits growth and metastasis
Molecular mechanism: cSMARCA5 could promote the expression of TIMP3, a well-known tumor suppressor, by sponging hsa-miR-17-3p and hsa-miR-181b-5p
Survival: better
Supported No.:
 3
Description:

Herein, we studied the role of cSMARCA5, a circular RNA, in hepatocellular carcinoma. Our in vitro and in vivo data showed that cSMARCA5 inhibits the growth and migration of hepatocellular carcinoma cells, making it a potential therapeutic target.
Other information
Title:

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.

Journal: J Hepatol
Published: 2018/1/30
PubMed ID: 29378234