circRNA basic information
circBase ID: hsa_circ_0001361
Name: hsa_circ_FNDC3B
Synonym: circFNDC3B
Host Gene: -
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Head, neck squamous cell carcinoma (HNSCC) cell lines (SCC4, HN4, HN6, FADU), human oral keratinocytes (HOK) cell lines
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: FUS, HIF1A, MDM2, VEGFA
Associated microRNA: -
Biological function: In vitro and in vivo functional assays showed that circFNDC3B accelerated the migration and invasion of OSCC cells and the tube-forming capacity of human umbilical vein endothelial cells and human lymphatic endothelial cells
Molecular mechanism: circFNDC3B/FUS/HIF1A/MDM2/VEGFA axis
Survival: -
Supported No.:
 1
Description:

Overall, these findings uncovered the mechanistic role of circFNDC3B in orchestrating cancer cell metastatic properties and vasculature formation, suggesting circFNDC3B could be a potential target to reduce OSCC metastasis.
Other information
Title:

circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma.

Journal: Cancer Res
Published: 2023/2/23
PubMed ID: 36811957