circRNA basic information
circBase ID: hsa_circ_0000591
Name: hsa_circ_MGA
Synonym: circ_0000591
Host Gene: hsa-miR-194-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: osteosarcoma cell lines (HOS, MG63, U2OS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HK2
Associated microRNA: hsa-miR-194-5p
Biological function: Silencing of circ_0000591 lessened cell viability, repressed cell proliferation, invasion, glycolysis, and promoted cell apoptosis
Molecular mechanism: circ_0000591/hsa-miR-194-5p/HK2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ_0000591 regulated HK2 expression by serving as a miR-194-5p molecular sponge.
Other information
Title:

Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression.

Journal: Clin Exp Pharmacol Physiol
Published: 2023/2/23
PubMed ID: 36809521