circRNA basic information
circBase ID: hsa_circ_0001715
Name: hsa_circ_LIMK1
Synonym: circ_0001715
Host Gene: hsa-miR-1249-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: bronchial epithelial cell line (BEAS-2B), NSCLC cell lines (PC9, NCI-H1299, HCC827, NCI-H1975, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FGF5
Associated microRNA: hsa-miR-1249-3p
Biological function: Circ_0001715 knockdown induced the inhibitory effects on proliferation, migration and invasion but the promoting effect on apoptosis of NSCLC cells
Molecular mechanism: circ_0001715/hsa-miR-1249-3p/FGF5 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

The current evidence elucidated that circ_0001715 served as an oncogenic regulator in NSCLC progression by depending on the miR-1249-3p/FGF5 axis.
Other information
Title:

Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5.

Journal: Biochem Genet
Published: 2023/2/23
PubMed ID: 36808266