circRNA basic information
circBase ID: hsa_circ_0001361
Name: hsa_circ_FNDC3B
Synonym: circFNDC3B
Host Gene: hsa-miR-525-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HO-1
Associated microRNA: hsa-miR-525-5p
Biological function: circFNDC3B promotes chondrocyte proliferation and protects the extracellular matrix (ECM) from degradation
Molecular mechanism: circFNDC3B/hsa-miR-525-5p/HO-1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In summary, we identified a new circFNDC3B/miR-525-5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-¦ĘB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA.
Other information
Title:

CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis.

Journal: Commun Biol
Published: 2023/2/23
PubMed ID: 36806251