circRNA basic information
circBase ID: hsa_circ_0023461
Name: hsa_circ_ARAP1
Synonym: circARAP1
Host Gene: hsa-miR-379-5p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: myocardial ischemia-reperfusion injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: cardiomyocytes HL-1
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF9
Associated microRNA: hsa-miR-379-5p
Biological function: loss-of-function assays were performed to show that circARAP1 suppression effectively ameliorated cardiomyocyte fibrosis and apoptosis in MI/RI mice
Molecular mechanism: circARAP1/hsa-miR-379-5p/KLF9 axis, Wnt signaling pathway
Survival: -
Supported No.:
 1
Description:

gain-of-function assays revealed that circARAP1 aggravated MI/RI in mice and H/R-induced cardiomyocyte injury by regulating the miR-379-5p/KLF9 axis to activate Wnt/beta-catenin signaling.
Other information
Title:

Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury.

Journal: Eur J Med Res
Published: 2023/2/22
PubMed ID: 36803446