circRNA basic information
circBase ID: hsa_circ_0000021
Name: hsa_circ_PLEKHM2
Synonym: circ_0000021
Host Gene: hsa-miR-3940-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human cervical epithelial cell line HcerEpiC, human CC cell lines (SiHa, C33A, CaSki, Hela)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KPNA2
Associated microRNA: hsa-miR-3940-3p
Biological function: Knocking down either hsa_circ_0000021 or KPNA2 repressed the growth of CC tumors as well as the proliferation, invasion, and migration of CC cells
Molecular mechanism: circ_0000021/hsa-miR-3940-3p/KPNA2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0000021 regulates the miR-3940-3p/KPNA2 axis to promote CC occurrence. This potentially is a novel target for CC treatment.
Other information
Title:

hsa_circ_0000021 sponges miR-3940-3p/KPNA2 expression to promote cervical cancer progression.

Journal: Curr Mol Pharmacol
Published: 2023/2/18
PubMed ID: 36799424