circRNA basic information
circBase ID: hsa_circ_0001103
Name: hsa_circ_SERPINE2
Synonym: cSERPINE2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IL-6, EIF4A3, CCL2
Associated microRNA: -
Biological function: tumor exosomal cSERPINE2 was shuttled to tumor associated macrophages (TAMs) and enhanced the secretion of Interleukin-6 (IL-6), leading to increased proliferation and invasion of breast cancer cells
Molecular mechanism: cSERPINE2/IL-6/EIF4A3/CCL2 axis
Survival: poor
Supported No.:
 1
Description:

Our study illustrates a novel mechanism that tumor exosomal cSERPINE2 mediates a positive feedback loop between tumor cells and TAMs to promote cancer progression, which may serve as a promising nanotherapeutic strategy for the treatment of breast cancer.
Other information
Title:

Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-kB-IL-6 axis of tumor-associated macrophages.

Journal: J Exp Clin Cancer Res
Published: 2023/2/17
PubMed ID: 36797769