circRNA basic information
circBase ID: hsa_circ_0128846
Name: hsa_circ_ZFR
Synonym: circ_0128846
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PC cell lines (CFPAC-1, Patu-8988t, PANC-1, SW1990), pancreatic non-cancer cell line (hTERT-HPNE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NR3C1
Associated microRNA: hsa-miR-1270
Biological function: Circ_0128846 deficiency restrained cancer cell proliferation, colony formation and migratory ability, enhanced cell apoptotic rate, and also impeded tumor development in vivo
Molecular mechanism: circ_0128846/hsa-miR-1270/NR3C1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0128846 deficiency blocked PC progression via mediating the miR-1270/NR3C1 pathway, which partly illustrated PC pathogenesis.
Other information
Title:

Hsa_circ_0128846 knockdown attenuates the progression of pancreatic cancer by targeting miR-1270/NR3C1 axis.

Journal: Sci Rep
Published: 2023/2/17
PubMed ID: 36797317