circRNA basic information
circBase ID: hsa_circ_0070401
Name: hsa_circ_PKD2
Synonym: circPKD2
Host Gene: hsa-miR-1278
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human astrocytes (NHA), glioma cells (T98G, LN229, A172)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: LATS2
Associated microRNA: hsa-miR-1278
Biological function: circPKD2 overexpression inhibited the cell proliferation, invasion, and glycolytic metabolism
Molecular mechanism: circPKD2/hsa-miR-1278/LATS2 axis, miRNA sponge
Survival: better
Supported No.:
 1
Description:

These findings display that circPKD2 can function as a tumor suppressor in glioma by controlling the miR-1278/LATS2 axis and provide the potential biomarkers for glioma treatment.
Other information
Title:

circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis.

Journal: Neurosci Lett
Published: 2023/2/17
PubMed ID: 36796622