circRNA basic information
circBase ID: hsa_circ_0034952
Name: hsa_circ_TUBGCP4
Synonym: circTUBGCP4
Host Gene: hsa-miR-146b-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCT116 cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PDK2
Associated microRNA: hsa-miR-146b-3p
Biological function: Silencing circTUBGCP4 expression in CRC cell-derived exosomes (CRC-CDEs) inhibited endothelial cell migration, tube formation, tip cell formation, and CRC metastasis. Overexpression of circTUBGCP4 had opposite results in vitro and in vivo
Molecular mechanism: circTUBGCP4/hsa-miR-146b-3p/PDK2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our results suggest that colorectal cancer cells generate exosomal circTUBGCP4, which causes vascular endothelial cell tipping to promote angiogenesis and tumor metastasis by activating Akt signaling pathway.
Other information
Title:

Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway.

Journal: J Exp Clin Cancer Res
Published: 2023/2/17
PubMed ID: 36793126