circRNA basic information
circBase ID: hsa_circ_0057021
Name: hsa_circ_TLK1
Synonym: circTLK1
Host Gene: hsa-miR-16-5p
 
 
 
Disease basic information
DO ID:
 3302
DO name: chordoma
Disease details: chordomas
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Chordoma cell line (U-CH1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Smad3
Associated microRNA: hsa-miR-16-5p
Biological function: circTLK1 interference suppressed chordoma cell proliferation and invasion
Molecular mechanism: circTLK1/hsa-miR-16-5p/Smad3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, our findings suggested that the disruption of the circTLK1/miR-16-5p/Smad3 positive feedback pathway, particularly via the Smad3 inhibitor SIS3, could be a promising therapeutic strategy.
Other information
Title:

The malignancy of chordomas is enhanced via a circTLK1/miR-16-5p/Smad3 positive feedback axis.

Journal: Cell Death Discov
Published: 2023/2/16
PubMed ID: 36792585