circRNA basic information
circBase ID: hsa_circ_0001947
Name: hsa_circ_AFF2
Synonym: circ-AFF2
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: renal cell carcinoma cell lines (ACHN, 786-O)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145
Biological function: Knockdown of circ-AFF2 or circ-ASAP1 in RCC cell lines inhibited proliferation, underscoring their oncogenic function
Molecular mechanism: circ-AFF2/hsa-miR-145 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

circ-AFF2 and circ-ASAP1 were upregulated in RCC and likely promote tumor progression by sponging miR-145.
Other information
Title:

Expression profiling of circular RNA reveals a potential miR-145-5p sponge function of circ-AFF2 and circ-ASAP1 in renal cell carcinoma.

Journal: Am J Transl Res
Published: 2023/2/14
PubMed ID: 36777845