circRNA basic information
circBase ID: hsa_circ_0008832
Name: hsa_circ_FBXO7
Synonym: circFBXO7
Host Gene: hsa-miR-296-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (A549, H226), mouse Lewis lung carcinoma (LLC) cell lines
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF15, CDKN1A
Associated microRNA: hsa-miR-296-3p
Biological function: Overexpression of circFBXO7 inhibited cell proliferation both in vitro and in vivo
Molecular mechanism: circFBXO7/hsa-miR-296-3p/KLF15/CDKN1A axis, miRNA sponge
Survival: better
Supported No.:
 1
Description:

CircFBXO7 acts as a tumor suppressor by a novel circFBXO7/miR-296-3p/KLF15/CDKN1A axis, which may serve as a potential biomarker and therapeutic target for NSCLC.
Other information
Title:

Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.

Journal: Transl Oncol
Published: 2023/2/13
PubMed ID: 36774884