circRNA basic information
circBase ID: hsa_circ_0000005
Name: hsa_circ_CDK11A
Synonym: circ_002136
Host Gene: hsa-miR-16-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines (SGC7901, BGC823)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA1
Associated microRNA: hsa-miR-16-5p
Biological function: knockdown of circ_002136 elevated the Tax sensitivity of Tax-resistant GC cells, inhibited the cell motility properties, and simultaneously drove the apoptosis
Molecular mechanism: circ_002136/hsa-miR-16-5p/HMGA1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Overall, our study revealed a novel signaling pathway that could be used for future clinical applications, namely the circ_002136/miR-16-5p/HMGA1 axis to regulate the Tax resistance of GC cells.
Other information
Title:

Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis.

Journal: Open Med (Wars)
Published: 2023/2/11
PubMed ID: 36760722