circRNA basic information
circBase ID: hsa_circ_0001925
Name: hsa_circ_KIF4A
Synonym: circ_0001925
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal breast epithelial cells (MCF-10A), human TNBC cell lines (BT-549BT-549, MDA-MB-231), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YY1
Associated microRNA: hsa-miR-1299
Biological function: Hsa_circ_0001925 silencing constrained cell proliferation, migration and angiogenesis whereas it promoted apoptosis in vitro, and hsa_circ_0001925 silencing significantly curbed xenograft tumor growth in vivo.
Molecular mechanism: circ_0001925/hsa-miR-1299/YY1 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

Our findings showed that hsa_circ_0001925 mediated TNBC progression via regulating miR-1299/YY1 axis, providing a potential target for BC treatment.
Other information
Title:

Hsa_circ_0001925 promotes malignant progression in triple-negative breast cancer via miR-1299/YY1 axis.

Journal: Thorac Cancer
Published: 2023/2/9
PubMed ID: 36754085