circRNA basic information
circBase ID: hsa_circ_0007468
Name: hsa_circ_PRDM4
Synonym: circPRDM4
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: HIF-1alpha, CD274
Associated microRNA: -
Biological function: In vitro and in vivo experiments showed that circPRDM4 induced PD-L1 expression and promoted CD8+ T cell-mediated immune escape under hypoxic conditions
Molecular mechanism: circPRDM4/HIF-1alpha/CD274 axis
Survival: -
Supported No.:
 1
Description:

These findings illustrated that circPRDM4 promoted immune escape of HCC cells by facilitating the recruitment of HIF-1alpha onto the promoter of CD274 under hypoxia, thereby inhibiting CD8+ T cell infiltration in the tumor microenvironment.
Other information
Title:

Hypoxia-associated circPRDM4 promotes immune escape via HIF-1alpha regulation of PD-L1 in hepatocellular carcinoma.

Journal: Exp Hematol Oncol
Published: 2023/2/8
PubMed ID: 36747292