circRNA basic information
circBase ID: hsa_circ_0001535
Name: hsa_circ_FAM13B
Synonym: circFAM13B
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: T24, UMUC3, HEK 293 T cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: IGF2BP1, PKM2
Associated microRNA: -
Biological function: The function of CD8+ T cells was promoted by circFAM13B, and it could attenuate the glycolysis of BCa cells and reverse the acidic tumour microenvironment (TME)
Molecular mechanism: circFAM13B/IGF2BP1/PKM2 axis, miRNA sponge
Survival: better
Supported No.:
 1
Description:

HNRNPL-induced circFAM13B could repress immune evasion and enhance immunotherapy sensitivity by inhibiting glycolysis and acidic TME in BCa through the novel circFAM13B/IGF2BP1/PKM2 cascade. Therefore, circFAM13B can be used as a biomarker for guiding the immunotherapy among patients with BCa.
Other information
Title:

HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.

Journal: J Exp Clin Cancer Res
Published: 2023/2/8
PubMed ID: 36747239