circRNA basic information
circBase ID: hsa_circ_0004913
Name: hsa_circ_TEX2
Synonym: circ_TEX2, circ_0004913
Host Gene: hsa-miR-96-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal liver cell line (THLE-2), hepatoma cell lines (Huh7, SK-HEP-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SPRED1
Associated microRNA: hsa-miR-96-5p
Biological function: Overexpression of circ_TEX2 could inhibit the proliferation, migration, and invasion and boost cell apoptosis of hepatoma cells.
Molecular mechanism: Circ_TEX2/hsa-miR-96-5p/SPRED1 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

Our study demonstrates the tumor-suppressive role of circ_TEX2 in hepatoma through miR-96-5p/SPRED1 axis, suggesting that strategies directed toward restoring the production of circ_TEX2 might have a therapeutic value for hepatoma treatment.
Other information
Title:

Circ_TEX2 Functions as a Tumor Suppressor in Hepatoma via miR-96-5p/SPRED1 Axis.

Journal: Mol Biotechnol
Published: 2023/2/7
PubMed ID: 36745282