circRNA basic information
circBase ID: -
Name: hsa_circ_ANKRD28
Synonym: circANKRD28
Host Gene: hsa-miR-221-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cells (SK-MES-1, H460, A549, H1299), normal lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SOCS3
Associated microRNA: hsa-miR-221-3p
Biological function: circANKRD28 overexpression inhibited DDP resistance in NSCLC cells in vitro
Molecular mechanism: circANKRD28/hsa-miR-221-3p/SOCS3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

The present study revealed the regulatory effects and molecular mechanism of circANKRD28 on the development and cisplatin resistance in NSCLC, which may provide experimental basis and theoretical support to identify new targets for therapy of DDP resistance in NSCLC.
Other information
Title:

circANKRD28 inhibits cisplatin resistance in non-small-cell lung cancer through the miR-221-3p/SOCS3 axis.

Journal: J Gene Med
Published: 2023/2/7
PubMed ID: 36740786