circRNA basic information
circBase ID: hsa_circ_0001789
Name: hsa_circ_RAB11FIP1
Synonym: circ_0001789
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (AGS, HGC27, MKN-45, MKN-74), primary human umbilical vein endothelial cells (HUVECs), human gastric mucosal epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PAK2
Associated microRNA: hsa-miR-140-3p
Biological function: Silencing circ_0001789 attenuated the malignancy of GC cells, and exosomal circ_0001789 was sufficient to regulate the malignant phenotype of GC cells.
Molecular mechanism: circ_0001789/hsa-miR-140-3p/PAK2 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

The present data suggested that the upregulation of circ_0001789 was associated with the progression of GC and with poor prognosis in patients with GC, and that miR-140-3p/PAK2 served as the downstream axis to mediate the oncogenic effect of circ_0001789.
Other information
Title:

Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer.

Journal: J Transl Med
Published: 2023/2/6
PubMed ID: 36740679