circRNA basic information
circBase ID: hsa_circ_0026218
Name: hsa_circ_CERS5
Synonym: circ_0026218
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HUVECs, human embryonic kidney (HEK)-293 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT6
Associated microRNA: hsa-miR-338-3p
Biological function: circ_0026218 overexpression promoted viability of HUVECs in vitro and inhibited inflammatory response, oxidative stress, and apoptosis
Molecular mechanism: circ_0026218/hsa-miR-338-3p/SIRT6 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Collectively, circ_0026218 upregulates SIRT6 expression through decoying miR-338-3p, thereby inhibiting ox-LDL-initiated injury of HUVECs. circ_0026218 is involved in the pathogenesis of AS.
Other information
Title:

Circular RNA circ_0026218 Suppressed Atherosclerosis Progression via miR-338-3p/SIRT6 Axis.

Journal: Biomed Res Int
Published: 2023/2/4
PubMed ID: 36733404