circRNA basic information
circBase ID: -
Name: hsa_circ_IPO7
Synonym: circIPO7
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: caprin-1, G3BP1, EGFR
Associated microRNA: -
Biological function: circIPO7 overexpression significantly suppressed GC cell proliferation in vitro and in vivo
Molecular mechanism: circIPO7/caprin-1/G3BP1/EGFR/mTOR axis
Survival: -
Supported No.:
 1
Description:

Thus, the complex containing overexpressed circIPO7 blocked the caprin-1-G3BP1 interaction and dissociated caprin-1 and its target mRNAs (EGFR and mTOR) from ribosomes, resulting in their translational inhibition, followed by PI3K/AKT/mTOR pathway inactivation.

Other information
Title:

circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR.

Journal: Oncogene
Published: 2023/2/3
PubMed ID: 36732659