circRNA basic information
circBase ID: -
Name: hsa_circ_PIP5K1A
Synonym: circ-PIP5K1A
Host Gene: hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NFIB
Associated microRNA: hsa-miR-942-5p
Biological function: Circ-PIP5K1A knockdown could constrain the proliferation, migration, and invasion, as well as increase apoptosis and sensitivity to DDP in DDP-resistant OC cells.
Molecular mechanism: circ-PIP5K1A/hsa-miR-942-5p/NFIB axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Besides that, circ-PIP5K1A was packaged into exosomes and exosomal circ-SKA3 could mediate intercellular communication between OC cells. These findings provided a promising therapeutic target for OC.
Other information
Title:

Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.

Journal: Anticancer Drugs
Published: 2023/2/3
PubMed ID: 36730637