circRNA basic information
circBase ID: hsa_circ_0011946
Name: -
Synonym: circ_0011946
Host Gene: hsa-miR-216a-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BCL2L2
Associated microRNA: hsa-miR-216a-5p
Biological function: Circ_0011946 knockdown impeded proliferation, migration, and invasion, but promoted apoptosis in OSCC cells
Molecular mechanism: Circ_0011946 functioned as a sponge for hsa-miR-216a-5p, and BCL2L2 was targeted by hsa-miR-216a-5p
Survival: -
Supported No.:
 3
Description:

Circ_0011946 silence repressed OSCC cell proliferation, migration, and invasion, but promoted apoptosis through the regulation of the miR-216a-5p/BCL2L2 axis.
Other information
Title:

Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells.

Journal: BMC Cancer
Published: 2021/10/9
PubMed ID: 34620126