circRNA basic information
circBase ID: hsa_circ_0091537
Name: hsa_circ_LOC286467
Synonym: circ_0091537
Host Gene: hsa-miR-520h
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: hsa-miR-520h
Biological function: Circ_0091537 knockdown inhibited gefitinib resistance in NSCLC cells and then inhibited NSCLC cell growth, migration, and invasion.
Molecular mechanism: circ_0091537/hsa-miR-520h/YAP1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0091537 strengthens gefitinib chemoresistance to promote NSCLC progression by mediating the miR-520h/YAP1 network, suggesting that circ_0091537 may be a key indicator in resistance to treatment of NSCLC.
Other information
Title:

Circ_0091537 promotes gefitinib chemoresistance in non-small cell lung cancer by mediating the miR-520h/YAP1 network.

Journal: Anticancer Drugs
Published: 2023/2/3
PubMed ID: 36727737