circRNA basic information
circBase ID: hsa_circ_0001185
Name: hsa_circ_IFNGR2
Synonym: circIFNGR2
Host Gene: hsa-miR-378
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OVCA cell lines (A2780, OV90), human normal ovarian epithelial cells (IOSE80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ST5
Associated microRNA: hsa-miR-378
Biological function: activation of exosomal circIFNGR2_locked cell proliferation, metastasis and EMT.
Molecular mechanism: circIFNGR2/hsa-miR-378/ST5 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our study revealed a previously unknown regulatory pathway whereby CAFs-derived exosomes delivered circIFNGR2 and inhibited the malignant progression of OVCA by circIFNGR2/miR-378/ST5 axis.
Other information
Title:

Exosome-transmitted circIFNGR2 Modulates Ovarian Cancer Metastasis via miR-378/ST5 Axis.

Journal: Mol Cell Biol
Published: 2023/2/1
PubMed ID: 36720469