circRNA basic information
circBase ID: hsa_circ_0000118
Name: hsa_circ_MAN1A2
Synonym: circ_0000118
Host Gene: hsa-miR-211-5p, hsa-miR-377-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human cervical epithelial cell line (H8), HeLa, CaSki, SiHa, HEK293 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT2
Associated microRNA: hsa-miR-211-5p, hsa-miR-377-3p
Biological function: Loss-of-function experiments demonstrated that circ_0000118 knockdown impaired the proliferation and tumor sphere formation, as well as the angiogenic potential of CC cells.
Molecular mechanism: circ_0000118/hsa-miR-211-5p/hsa-miR-377-3p/AKT2 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Our study suggested that circ_0000118 functions as an oncogenic factor in progression of CC by maintaining AKT2 level through targeting miR-211-5p and miR-377-3p as a ceRNA (competitive endogenous RNA), which provides novel therapeutic target in the management of CC.
Other information
Title:

CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.

Journal: Biochem Genet
Published: 2023/2/1
PubMed ID: 36719624