circRNA basic information
circBase ID: hsa_circ_0001742
Name: hsa_circ_SMO
Synonym: circRNA-SMO
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human astrocyte cell line (NHA), glioblastoma cell lines (U118, U251, U87MG, LN229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CEP85
Associated microRNA: hsa-miR-326
Biological function: CircRNA-SMO downregulation inhibited the viability and colony-forming ability of the glioblastoma cells.
Molecular mechanism: circRNA-SMO/hsa-miR-326/CEP85 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircRNA-SMO sponges miR-326 to promote glioblastoma proliferation and migration by upregulating CEP85 expression. This study clarified the role of circRNA-SMO in the development of glioblastoma, providing novel insights for its treatment.
Other information
Title:

circRNA-SMO upregulates CEP85 to promote proliferation and migration of glioblastoma via sponging miR-326.

Journal: Histol Histopathol
Published: 2023/2/1
PubMed ID: 36718820