circRNA basic information
circBase ID: hsa_circ_0119412
Name: hsa_circ_PER2
Synonym: circ_0119412
Host Gene: hsa-miR-186-5p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: RB cells (SO-RB50, HXO-RB44, Y79), retinal pigment epithelial cells (ARPE-19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ELK4
Associated microRNA: hsa-miR-186-5p
Biological function: In vitro assay revealed that downregulating circ_0119412 accelerated the cell apoptosis of RB cells and slowed down their migration and proliferation, and the in vivo assay indicated that circ_0119412 downregulation reduced the weight and volume of tumor in nude mice.
Molecular mechanism: circ_0119412/hsa-miR-186-5p/ELK4 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0119412 was found to be upregulated in RB, and could accelerate the progression of RB via the miR-186-5p/ELK4 axis, indicating circ_0119412 may serve a promising clinical therapeutic target of RB.
Other information
Title:

Hsa_circ_0119412 Contributes to Development of Retinoblastoma by Targeting miR-186-5p/ELK4 Axis.

Journal: Mol Biotechnol
Published: 2023/1/31
PubMed ID: 36715861