circRNA basic information
circBase ID: hsa_circ_0072765
Name: hsa_circ_CCNB1
Synonym: circ_0072765
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: liver fibrosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HSCs (LX2 cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRPV3
Associated microRNA: hsa-miR-197-3p
Biological function: Hsa_circ_0072765 knockdown inhibited cell proliferation, cell cycle, activation and migration in TGF-beta-induced HSCs. Hsa_circ_0072765 sponged miR-197-3p and negatively regulated miR-197-3p expression.
Molecular mechanism: circ_0072765/hsa-miR-197-3p/TRPV3 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Hsa_circ_0072765 promoted the progression of TGF-beta-treated HSCs by decoying miR-197-3p and upregulating TRPV3.
Other information
Title:

Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-beta)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis.

Journal: Histol Histopathol
Published: 2023/1/31
PubMed ID: 36714978