circRNA basic information
circBase ID: hsa_circ_0044411
Name: hsa_circ_ZNF652
Synonym: circ_0044411
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 10533
DO name: viral pneumonia
Disease details: infantile pneumonia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lung fibroblast cell line (MRC-5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCL16
Associated microRNA: hsa-miR-141-3p
Biological function: Circ_0044411 could promote the cell viability and proliferation, inhibit inflammatory response and apoptosis in LPS-induced MRC-5 cells.
Molecular mechanism: circ_0044411/hsa-miR-141-3p/CCL16 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

Circ_0044411 knockdown promoted cell viability and proliferation, inhibited inflammatory response and apoptosis by regulating miR-141-3p/CCL16 axis, indicating that circ_0044411 might be a potential therapeutic target for IP.
Other information
Title:

Circ_0044411 silencing protects infantile pneumonia from lipopolysaccharide-induced cell injury by sponging miR-141-3p to inhibit CCL16 expression.

Journal: Int Immunopharmacol
Published: 2023/1/27
PubMed ID: 36700761