circRNA basic information
circBase ID: hsa_circ_0058063
Name: hsa_circ_ATIC
Synonym: circ-ATIC
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal immortalized human esophagus epithelial cell line (HET-1A), human ESCC cell lines (KYSE-510, KYSE-520)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PBX3
Associated microRNA: hsa-miR-1294
Biological function: Circ-ATIC knockdown substantially reduced proliferation and the number of invaded ESCC cells and retarded EMT process, reflecting by the decreased N-cadherin and elevated E-cadherin.
Molecular mechanism: circ-ATIC/hsa-miR-1294/PBX3 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Collectively, circ-ATIC promoted ESCC proliferation and invasion by regulating miR-1294/PBX3 axis.
Other information
Title:

Circ-ATIC regulates esophageal squamous cell carcinoma growth and metastasis through miR-1294/PBX3 pathway.

Journal: Heliyon
Published: 2023/1/27
PubMed ID: 36699282