circRNA basic information
circBase ID: hsa_circ_0000396
Name: hsa_circ_SCL38A1
Synonym: circSCL38A1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human urothelial line (SV-HUC-1), bladder transitional cell carcinoma cell lines (UMUC3, J82, T24, RT4, SW780), Grade II bladder carcinoma cell line (5637)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: ILF3
Associated microRNA: -
Biological function: Functional assays showed that circSLC38A1 promoted BC cell invasion in vitro and lung metastasis of mice in vivo.
Molecular mechanism: circSCL38A1/ILF3/TGF-beta2 signaling axis
Survival: -
Supported No.:
 1
Description:

Thus, our study revealed an essential role and clinical significance of circSLC38A1 in BC via activating the transcription of TGF-beta2 in an ILF3-dependent manner, extending the understanding of the importance of circRNA-mediated transcriptional regulation in BC metastasis.
Other information
Title:

Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-beta2 signaling axis.

Journal: Cell Death Dis
Published: 2023/1/26
PubMed ID: 36697384